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Several of the small-flowered species of Hoodia were formerly in a separate genus, Trichocaulon ("ghaap"), but have been moved into the genus Hoodia, and the two groups are now synonymous. Those of larger-flowered species (such as Hoodia gordonii) are often a papery pink-tan colour, plate-shaped, with an unpleasant smell to attract their fly pollinators. They have a branching, shrub-like form, and the largest species (Hoodia parviflora) can grow to the size of a tree - over 2 m (6 ft 7 in) in height. Even though weight loss can improve health, it’s not always easy to lose excess body fat and maintain that weight loss over time. In 2006, the plant became internationally known, after a marketing campaign falsely claimed that its use as a dietary supplement was an appetite suppressant for weight loss. In a case of biopiracy, bioprospectors from South Africa's Council for Scientific and Industrial Research (CSIR) realized that the plant was marketable and patented its use as an appetite suppressant without recognizing the Sans' traditional claims to the knowledge of the plant and its uses.

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